While most superficial skin or vaginal infections do well with creams and ointments, they often come back. In particular, vaginal infections can be hard to cure, like if they are due to a resistant strain of yeast.
Invasive or Chronic Systemic Infections
Controlling these infections may involve weeks to months of systemic antifungal drugs. Your health care provider will watch for overall health issues, as well as related issues like nutrition, blood sugar and catheters, that might be causing the problem. If your overall health gets better and you find an antifungal therapy that works, chronic systemic infections can be stopped. But in some cases a long-term infection means that you have some other health problem that must be treated before the yeast infection can be cured.