Bone-targeted Therapy

If you have advanced prostate cancer or are taking hormonal therapy, your provider may suggest calcium or Vitamin D for your bones. Some drugs can also help strengthen and protect your bones. These include Denosumab (Xgeva®) and Zoledronic Acid (Zometa®). Both help prevent bad side effects from the cancer growing in your bones. These side effects can include bone thinning, bone breaks and bone pain. 

Radium-223 (Xofigo®) is another new treatment approved for men whose mCRPC has spread to their bones. This treatment is injected in your veins. It collects in the bones where cancer has spread and is growing fast.

Once in the bones it gives off small amounts of radiation that can only travel short distances. This can target radiation to the exact areas of the bone where cancer cells are growing. Radium-223 has been shown to help men live longer.

With Radium-223, your PSA level does not show how well you are responding. Although your PSA level may increase, this does not mean that the treatment is not working. 

Updated August 2018

Related Resources


Other Groups' Resources

Advocacy Connector

Use the Advocacy Connector to search director listing of national and select state resources for patients and caregivers, including helplines, support, clinical trials information, and financial, legal and insurance assistance.

American Association of Sexuality Educators, Counselors and Therapists (AASECT)

Your urologist may be able to refer you to medical professionals and counselors who specialize in erectile dysfunction after prostate cancer. AASECT also has a directory you can use to find a certified sex therapist near you.

Caregiver Action Network

The Caregiver Action Network offers a family caregiver forum and toolbox of resources.

Hormone Health Network

Osteoporosis and Men's Health Fact Sheet
Prostate Cancer and Bone Loss Fact Sheet

National Cancer Institute at the National Institutes of Health

Prostate Cancer

National Comprehensive Cancer Network

The National Comprehensive Cancer Network lists information on clinical trials; life with cancer; life after cancer; and payment assistance.


Prostate Cancer (English)
Cáncer de próstata (Español)

Patient Access Network Foundation (PAN Foundation)

The PAN Foundation offers co-pay assistance for metastatic castrate resistant prostate cancer.

Patient Advocacy Foundation

The Patient Advocacy Foundation Patient Services program provides patients with case management to assist with access to care, medical debt and job retention related to their illness.

USToo International, Inc.

Find a support group near you.

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