This therapy is for those with metastatic prostate cancer (mCRPC) and no symptoms.

What is immunotherapy?

Researchers are now using the body's own immune system to treat mCRPC. If prostate cancer returns despite hormone therapy and is metastatic, your health care provider may offer Sipuleucel-T (Provenge®).

Sipuleucel-T works by boosting your immune system so it attacks cancer cells. Other prostate cancer immunotherapies are also being studied.

What are the benefits, risks and side effects of immunotherapy?

Immunotherapy boosts the immune system. It may extend survival by months for some patients. This is the first immunotherapy that has been shown to help men with prostate cancer live longer.

Side effects may include fever, chills, weakness, headache, nausea, vomiting and diarrhea. The patient may also have low blood pressure and rashes.

Who are good candidates for immunotherapy?

Immunotherapy is given to mCRPC patients before chemotherapy. There may also be patients who get chemotherapy and immunotherapy together. For immunotherapy, the patient needs to have no or mild symptoms. If chemotherapy was started before symptoms or chemotherapy causes symptoms to go away, immunotherapy is a possible choice.

Updated August 2018

Related Resources


Other Groups' Resources

Advocacy Connector

Use the Advocacy Connector to search director listing of national and select state resources for patients and caregivers, including helplines, support, clinical trials information, and financial, legal and insurance assistance.

American Association of Sexuality Educators, Counselors and Therapists (AASECT)

Your urologist may be able to refer you to medical professionals and counselors who specialize in erectile dysfunction after prostate cancer. AASECT also has a directory you can use to find a certified sex therapist near you.

Caregiver Action Network

The Caregiver Action Network offers a family caregiver forum and toolbox of resources.

Hormone Health Network

Osteoporosis and Men's Health Fact Sheet
Prostate Cancer and Bone Loss Fact Sheet

National Cancer Institute at the National Institutes of Health

Prostate Cancer

National Comprehensive Cancer Network

The National Comprehensive Cancer Network lists information on clinical trials; life with cancer; life after cancer; and payment assistance.


Prostate Cancer (English)
Cáncer de próstata (Español)

Patient Access Network Foundation (PAN Foundation)

The PAN Foundation offers co-pay assistance for metastatic castrate resistant prostate cancer.

Patient Advocacy Foundation

The Patient Advocacy Foundation Patient Services program provides patients with case management to assist with access to care, medical debt and job retention related to their illness.

USToo International, Inc.

Find a support group near you.

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