Third Phase: Neuromodulation, Ulcer Cauterization and Injections

Neuromodulation Therapy 

If lifestyle changes and prescription drugs don't work, or pain or side effects interfere with your quality of life, more advanced therapies may be a better choice.  You will most likely be referred to a specialist who treats patients with IC/BPS, such as a urologist.  After reviewing your treatment history, the specialist may suggest neuromodulation therapy. Neuromodulation therapy is the name given to a group of treatments that deliver harmless electrical impulses to nerves to change how they work.   

Bladder Ulcer Cauterization

If you have a bladder ulcer, having it cauterized under anesthesia or having steriod injections may give long-term relief for up to a year or more. This treatment can be repeated if necessary.


Some injections of Botox® can be given if other treatments have not provided adequate symptom control and there is no improvement in quality of life.  Small doses of this drug can paralyze muscles.  When injected into the bladder muscle, it may help with the pain of IC/BPS.  This treatment can wear off, and you may need to have another treatment 6 to 9 months after the first injection.  Your health care provider should follow you closely to watch for complications, including difficulty in passing urine.


Other Groups' Resources


Interstitial Cystitis (English)
Cistitis intersticial (Español)

National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC)

Interstitial Cystitis/Painful Bladder Syndrome (English)
Lo que usted debe saber sobre la cistitis intersticial (sìndrome de vejiga dolorosa) (Español)

The International Painful Bladder Foundation

Interstitial Cystitis Association

Interstitial Cystitis Network